Roche Platform Transition

This page compares reference ranges between the Roche and Beckman platforms for the selected category of tests. For a description of the transition from the Beckman to Roche automated chemistry platform, please see the Chemistry and Immunoassay Beckman to Roche Transition Guideline.

Method Comparison

The comparison table contains the following columns:

  • Trendable?: Indicates whether both methods use the same component code and results are trendable in Epic.
  • Bias: The average absolute difference between Roche and Beckman results. A positive value means Roche results are higher on average.
  • Percent Bias: Blue shading and bars extending left indicate negative bias (Beckman higher on average); orange shading and bars extending right indicate positive bias (Roche higher on average). Longer bars indicate greater magnitude.
  • Slope: The slope of the linear regression of Roche onto Beckman, representing proportional bias between the methods. “Not comparable” indicates that the methods were too poorly correlated for direct patient-result comparison.
  • R2 (Coefficient of Determination): How closely the regression fits the paired results.

These data can help when comparing results across platforms, but should not be used to convert a result directly from one method to the other.

Test Name Beckman Roche Trendable? Bias Percent Bias Slope Coefficient of Determination (R2)
Alpha Fetoprotein, Nonmaternal AFPNOT AFPTRD Not comparable
Beta 2 Microglobulin, Serum BETA2 BETA2 0.31 mcg/mL 12.48% 0.88 0.9622
CA 125 CA125R C125RD Not comparable
CA 15.3 CA153R C153RD Not comparable
CA 19.9 CA199 C199RD Not comparable
Carcinoembryonic Antigen CEA CEARD Not comparable
Prostate Specific Antigen PSA PSARD Not comparable
Prostate Specific Antigen Screen PSASCR PSASRD Not comparable
Prostate Specific Antigen, Free PSAF PSAFRD Not comparable

Reference Ranges

Name
Beckman
Roche
Alpha Fetoprotein, Nonmaternal
Name: Alpha Fetoprotein, Nonmaternal (Beckman)
Mnemonic: AFPNOT
Units: ng/mL
Method Code: default
Female Male
AgeRange AgeRange
3y- 0.0-8.5 3y- 0.0-8.5
Effective date: 08/14/2009
Name: Alpha Fetoprotein, Nonmaternal (Roche)
Mnemonic: AFPTRD
Units: ng/mL
Method Code: default
Female Male
AgeRange AgeRange
0- 0.0-8.2 0- 0.0-8.2
Effective date: 09/02/2026
Beta 2 Microglobulin, Serum
Name: Beta 2 Microglobulin, Serum
Mnemonic: BETA2
Units: mcg/mL (units differ between platforms)
Method Code: default
Female Male
AgeRange AgeRange
0-59y 0.8-2.4 0-59y 0.8-2.4
60y- 0.0-3.0 60y- 0.0-3.0
Effective date: 09/14/2026
Name: Beta 2 Microglobulin, Serum
Mnemonic: BETA2
CA 125
Name: CA 125 (Beckman)
Mnemonic: CA125R
Units: U/mL
Method Code: default
Female Male
AgeRange AgeRange
0- 0-35 0- 0-35
Effective date: 03/01/2016
Name: CA 125 (Roche)
Mnemonic: C125RD
Units: U/mL
Method Code: default
Female Male
AgeRange AgeRange
0- 0-38 0- 0-38
Effective date: 04/19/2026
CA 15.3
Name: CA 15.3 (Beckman)
Mnemonic: CA153R
Units: U/mL
Method Code: default
Female Male
AgeRange AgeRange
0- 0-20 0- 0-20
Effective date: 10/17/2016
Name: CA 15.3 (Roche)
Mnemonic: C153RD
Units: U/mL
Method Code: default
Female Male
AgeRange AgeRange
0- 0-29 0- 0-29
Effective date: 09/02/2026
CA 19.9
Name: CA 19.9 (Beckman)
Mnemonic: CA199
Units: U/mL
Method Code: default
Female Male
AgeRange AgeRange
0- 0-54 0- 0-54
Effective date: 01/04/2017
Name: CA 19.9 (Roche)
Mnemonic: C199RD
Units: U/mL
Method Code: default
Female Male
AgeRange AgeRange
0- 0-34 0- 0-34
Effective date: 09/02/2026
Carcinoembryonic Antigen
Name: Carcinoembryonic Antigen (Beckman)
Mnemonic: CEA
Units: ng/mL
Method Code: default
Female Male
AgeRange AgeRange
0- 0.0-5.0 0- 0.0-5.0
Effective date: 05/31/2024
Name: Carcinoembryonic Antigen (Roche)
Mnemonic: CEARD
Units: ng/mL
Method Code: default
Female Male
AgeRange AgeRange
0- 0.0-3.7 0- 0.0-3.7
Effective date: 09/02/2026
Prostate Specific Antigen
Name: Prostate Specific Antigen (Beckman)
Mnemonic: PSA
Units: ng/mL
Method Code: default
Female Male
AgeRange AgeRange
0- 0.00-4.00 0- 0.00-4.00
Effective date: 12/02/2015
Name: Prostate Specific Antigen (Roche)
Mnemonic: PSARD
Units: ng/mL
Method Code: default
Female Male
AgeRange AgeRange
0-39y 0.00-2.00
40y-49y 0.00-2.50
50y-59y 0.00-3.50
60y-69y 0.00-4.50
70y-79y 0.00-6.50
80y- 0.00-7.20
Effective date: 09/02/2026
Prostate Specific Antigen Screen
Name: Prostate Specific Antigen Screen (Beckman)
Mnemonic: PSASCR
Units: ng/mL
Method Code: default
Female Male
AgeRange AgeRange
0- 0.00-4.00 0- 0.00-4.00
Effective date: 01/25/2019
Name: Prostate Specific Antigen Screen (Roche)
Mnemonic: PSASRD
Units: ng/mL
Method Code: default
Female Male
AgeRange AgeRange
0-39y 0.00-2.00
40y-49y 0.00-2.50
50y-59y 0.00-3.50
60y-69y 0.00-4.50
70y-79y 0.00-6.50
80y- 0.00-7.20
Effective date: 09/02/2026
Prostate Specific Antigen, Free
Name: Prostate Specific Antigen, Free (Beckman)
Mnemonic: PSAF
Units: ng/mL
Method Code: default
Name: Prostate Specific Antigen, Free (Roche)
Mnemonic: PSAFRD
Units: ng/mL
Method Code: default Effective date: 09/02/2026