Zika, Chikungunya, and Dengue Antibody Panel (Sendout)

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General Information

Lab Name
Lab Code
655
External Test Id
0093096, 2011812, MZIKV
Description

Test Information: This panel includes testing for antibodies to Zika Virus, Chikungunya Virus (ChikV), and Dengue Fever Virus. This assay should be used in patients presenting at least 2 weeks postsymptom onset or last possible exposure to Zika virus. Reverse transcription-polymerase chain reaction (RT-PCR) for Zika virus RNA detection should be ordered in patients with less than 2 weeks of symptoms or postexposure.

Tests Included:

Zika IgM Capture ELISA is used under the Food and Drug Administration’s Emergency Use Authorization.

Synonyms
0093096, 2011812, Chikungunya, CHIKV, Dengue Fever, Flavivirus, MZIKV, Zika Virus

Interpretation

Method
  • Chikungunya Antibodies, IgG and IgM: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
  • Dengue Fever Virus Antibodies, IgG and IgM: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
  • Zika IgM: IgM Antibody Capture Enzyme-Linked Immunosorbent Assay (MAC-ELISA)
Guidelines

Ordering & Collection

Specimen Type
Blood
Collection

15 mL blood in GOLD SST or RED TOP tube

Handling Instructions
Quantity
requested: Chikungunya: 1 ml serum; Dengue: 1 ml serum; Zika: 2.5 ml serum
minimum: Chikungunya: 0.15 ml serum; Dengue: 0.1 ml serum; Zika: 2.0 ml serum

Processing

Processing

Panel includes the three tests indicated below. Refer to individual test guides for additional processing information.

  1. Chikungunya Virus IgG and IgM Antibodies (Sendout) [RCHIKV] - Refrigerated serum
  2. Dengue Fever IgG and IgM Antibody (Sendout) [RDFAGM] - Refrigerated serum
  3. Zika Virus Antibody, IgM (Sendout) [RZIKM] - Frozen serum

Sendouts:

  • Order ARUP Tests: 2011812 (Chikungunya) and 0093096 (Dengue).
  • Order Mayo Test: MZIKV (Zika). Provide answers to the questions (3) indicated in the general information section when ordering in MayoAccess.

Stability:

  • Chikungunya (ARUP 2011812): Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles); Ambient: 48 hours.
  • Dengue (ARUP 0093096): Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles); Ambient: 48 hours.
  • Zika (Mayo MZIKV): Frozen: 30 days; Refrigerated: Unacceptable; Ambient: Unacceptable.

Performance

LIS Dept Code
Performing Location(s)
Sendout ARUP Laboratories, Inc.
800-522-2787

500 Chipeta Way
Salt Lake City, UT 84108
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-1710

3050 Superior Drive NW
Rochester, MN 55901
Frequency
Refer to individual test guide listings.
Available STAT?
No

Billing & Coding

CPT codes
LOINC