IA-2 Antibody (Sendout)

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General Information

Lab Name
IA 2 Antibody (Sendout)
Lab Code
RIA2A
Epic Name
IA-2 Antibody (Sendout)
External Test Id
IA2
Description

Useful For:

  • Clinical distinction of type 1 from type 2 diabetes mellitus
  • Identification of individuals at risk of type 1 diabetes (including high-risk relatives of patients with diabetes)
  • Prediction of future need for insulin treatment in adult-onset diabetic patients

Not recommended in routine evaluation or management of diabetes mellitus (DM).

    ***Ordering Note: Effective 08/18/2025, this test is offline at Mayo Clinic Laboratories. Samples will be temporarily forwarded by Mayo to Esoterix Endocrinology and reported under Reference Laboratory Test 1 (SEND1) due to accompanying change in method and reference range.***

    References
    Synonyms
    Anti-IA2 Antibodies, Beta-Cell Autoantibody to IA-2, IA2, ICA-512, Insulinoma Associated 2 Antibody, Islet cell antigen - 512
    Components
    Code Name
    RIA2AR IA 2 Antibody

    Interpretation

    Method

    Esoterix Laboratory Method: Enzyme-linked Immunosorbent Assay (ELISA)

    Reference Range
    See individual components
    Ref. Range Notes

    Esoterix Laboratory Reference Values (for samples arriving at Mayo after 08/17/25):

    Negative: <7.5 U/mL
    Positive: > or = 7.5 U/mL
    Interferences and Limitations

    Cautions: Negative results do not exclude the diagnosis of or future risk for type 1 diabetes mellitus. The risk of developing type 1 diabetes may be stratified further by testing for antibodies targeting insulin, glutamic acid decarboxylase, and zinc transporter 8 (ZnT8) and human leukocyte antigen genetic markers. Careful monitoring of hyperglycemia is the mainstay of determining the requirement for insulin therapy.

    References

    Ordering & Collection

    Specimen Type
    Blood
    Collection

    3 mL blood in GOLD SST or RED TOP tube

    Handling Instructions

    Outside Laboratories: Centrifuge sample and aliquot serum to a separate plastic vial. Freeze at -20°C while awaiting shipment. Transport on dry ice.

    Stability: Frozen (preferred): 107 days; Refrigerated: 72 hours; Ambient: 72 hours.

    Quantity
    Requested: 1 mL serum
    Minimum: 0.5 mL serum (Note: Minimum volume does not allow for repeat analysis)

    Processing

    Receiving Instructions

    Centrifuge sample and aliquot serum to a separate plastic vial. Freeze serum at -20°C.

    Sendouts:

    • Order Mayo Test: FIAAB
    • Interfaced: No

    Stability: Frozen (preferred): 107 days; Refrigerated: 72 hours; Ambient: 72 hours.

    Misc Sendout

    Performance

    Lab Department
    Sendouts Mayo Lab (RF)(MARF)
    Frequency
    Performed: Varies. Reported: 7-14 days from sample receipt at Mayo Clinic Labs.
    Available STAT?
    No
    Performing Location(s)
    Sendout Mayo forwards to Esoterix Endocrinology, Inc.
    800-533-1710

    4301 Lost Hills Road
    Calabasas Hills, CA 91301

    Billing & Coding

    CPT Codes
    86341
    LOINC
    81155-4
    Interfaced Order Code
    UOW3771