Galactose Alpha 1,3 Galactose, IgE (Sendout)
General Information
- Lab Name
- Galactose Alpha 1,3 Galactose, IgE (Sendout)
- Lab Code
- RALGAG
- Epic Ordering
- Galactose-Alpha-1, 3-Galactose, IgE (Sendout)
- External Test Id
- ALGAL
- Description
Useful For:
- As an aid in diagnosis of an IgE mediated hypersensitivity allergy to red meat or meat-derived products such as beef, pork, venison, and gelatin
- This test is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists.
- This test is not useful for patients in whom the medical management does not depend upon identification of allergen specificity.
Highlights:
- The presence of IgE antibodies against galactose-alpha-1,3-galactose (alpha-gal) is associated with red meat allergy.
- Individuals with IgE antibodies against alpha-gal might develop anaphylactic reactions to the drug cetuximab.
- Other meat allergen IgE antibody tests may be considered in addition to galactose-alpha-1,3-galactose IgE antibody testing in cases of suspected red meat allergy.
- Synonyms
- ALGAL, alpha gal, Alpha Gal IgE, Alpha-Gal, alphagal, Galactose IgE, Galactose-alpha-1 3
- Components
-
Code Name RALGAL Galactose Alpha 1,3 Galactose, IgE (Sendout) RALGLI Galactose Alpha 1,3 Galactose, IgE UW438 Imm Study_Alpha Gal IgE
Interpretation
- Method
Fluorescence Enzyme Immunoassay (FEIA)
- Reference Range
- See individual components
- Ref. Range Notes
Class IgE kU/L Interpretation 0 <0.10 Negative 0/1 0.10-0.34 Borderline/equivocal 1 0.35-0.69 Equivocal 2 0.70-3.49 Positive 3 3.50-17.4 Positive 4 17.5-49.9 Strongly positive 5 50.0-99.9 Strongly positive 6 > or =100 Strongly positive Concentrations > or =0.70 Ku/L (Class 2 and above) will flag as abnormally high. Reference values apply to all ages.
Interpretation:
Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be responsible for eliciting signs and symptoms.
The level of IgE antibodies in serum varies directly with the concentration of IgE antibodies expressed as a class score or kU/L.
- Interferences and Limitations
Cautions:
Some individuals with clinically insignificant sensitivity to allergens may have measurable levels of IgE antibodies in serum, and results must be interpreted in the clinical context.
False-positive results for IgE antibodies may occur in patients with markedly elevated serum IgE (>2500 kU/L) due to nonspecific binding to allergen solid phases.
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
3 mL blood in RED TOP tube or GOLD SST
- Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Stability: Refrigerated (preferred): 14 days; Frozen: 90 days; Ambient: Unacceptable.
- Quantity
-
requested: 0.5 mL serum + 0.5 mL serum for UW438
minimum: 0.5 mL serum
Processing
- Processing
Centrifuge sample and transfer serum to two separate plastic vials. If sample volume is low, prioritize the sendout test.
- RALGAL: Store serum refrigerated in the Mayo Sendouts rack (95).
- UW438: Store serum frozen in Immunology -70°C rack (44).
Sendouts:
- Order Mayo Test: ALGAL.
- Interfaced: Yes.
Stability: Refrigerated (preferred): 14 days; Frozen: 90 days; Ambient: Unacceptable.
Performance
- LIS Dept Code
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-17103050 Superior Drive NW
Rochester, MN 55901 - Frequency
- Performed: Monday - Friday. Report Available: 1-3 days.
- Available STAT?
- No
Billing & Coding
- CPT codes
- 86008
- LOINC
- 73837-7