1:1 Mix _ Prothrombin Time

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General Information

Lab Name
1:1 Mix _ Prothrombin Time
Lab Code
PROX1P
Epic Ordering
1:1 MIX _ PROTHROMBIN TIME
Description

A protime mixing study is ordered to evaluate the prolongation of Prothrombin Time (PT) only. It is used to distinguish the cause of prolonged PT due to factor deficiency or inhibitor. A 1:1 mix of the patient's plasma and normal pooled plasma is performed and the PT is measured again. If the PT corrects, this suggests a factor deficiency. If the PT does not correct, this suggests presence of an inhibitor. A mixing study interpretation may direct further coagulation testing.

Synonyms
Mix-Prothrombin 1:1, Prothrombin -Mix 1:1
Components

Interpretation

Method

Clot based

Reference Range
See individual components
Ref. Range Notes

For interpretation contact the Lab Med Resident on-call through the paging operator at 206-598-6190.

Ordering & Collection

Specimen Type
Blood
Collection

Two 3 mL plastic BLUE TOP (Citrate) Tubes

Handling Instructions

The Laboratory MUST process specimen, within 6 hrs of blood collection.

Quantity
requested: entire sample

Processing

Processing

UW-MT/HMC: Take specimen to the Coag bench for processing.

Outside Laboratory: Centrifuge for 10 minutes, remove plasma & re-spin plasma for another 10 minutes. Decant & Freeze plasma (minimum 2.0 mL) @ -20°C to -80°C. Send Frozen on dry ice.

Performance

LIS Dept Code
Performing Location(s)
HMC Coagulation
206-520-4600

325 9th Ave, Rm # GWH-47, Seattle, WA 98104-2420
UW-MT Coagulation
206-520-4600

Clinical Lab, Room NW220,
University of Washington Medical Center,
1959 NE Pacific street, Seattle, WA 98195
Frequency
Daily
Available STAT?
Yes, Daily 7 am – 10 pm. For other times, contact the Lab Medicine Resident for approval.

Billing & Coding

CPT codes
85610, 85611
LOINC
18720-3
Interfaced Order Code
UOW4751