Anti Neuronal Cell Antibody

tabbed view

General Information

Lab Name
Anti Neuronal Cell Ab
Lab Code
ANEUR
Epic Ordering
Anti Neuronal Cell Antibody
Description

Elevated serum or CSF anti-neuronal cell antibody levels may help in the diagnosis of neuropsychiatric systemic lupus erythematosus (SLE). This test should not be mistaken for the assay for anti-neuronal nuclear antibodies (ANNA), which include anti-Hu, Yo, and Ri antibodies. These other tests may be ordered to evaluate some forms of paraneoplastic peripheral neuropathies associated with various malignancies, and are not currently performed at the University of Washington (they are send-out tests).

References
  1. Ho RC, Thiaghu C, Ong H, Lu Y, Ho CS, Tam WW, Zhang MW. A meta-analysis of serum and cerebrospinal fluid autoantibodies in neuropsychiatric systemic lupus erythematosus. Autoimmun Rev. 2016 Feb;15(2):124-38. doi: 10.1016/j.autrev.2015.10.003. Epub 2015 Oct 23. PMID: 26497108.
  2. West SG, Woodruff E, Wener MH, Kotzin BL. Neuropsychiatric Lupus Erythematosus: A 10-year prospective study on the value of diagnostic tests. Am J Med (1995) 99:153.
Synonyms
Components

Interpretation

Method

ELISA using stable, isolated neuronal membrane extracts.

Reference Range
See individual components
Ref. Range Notes

Established by testing healthy blood donor samples during method validation in 1987. Confirmed in 2005, 2010, 2012, 2015, and 2018.

Guidelines

Ordering & Collection

Specimen Type
Blood
Collection

3 mL blood in RED TOP or SST tube

Handling Instructions
Quantity
requested: 1 mL serum
minimum: 0.5 mL serum

Processing

Processing

Freeze serum at -20°C

Stability: Freezer: Long Term; Refrig: 14 d

Performance

LIS Dept Code
Immunology (IMM)
Performing Location(s)
UW-MT Immunology
206-520-4600

Clinical Lab, Room NW220,
University of Washington Medical Center,
1959 NE Pacific street, Seattle, WA 98195
Frequency
Monday, Wednesday
Available STAT?
No

Billing & Coding

CPT codes
83520
LOINC
32853-4
Interfaced Order Code
UOW156