Echinococcus IgG Antibody, Serum (Sendout)

General Information

Lab Name

Lab Code

395

External Test Id

ECHNG

Description

Useful For: Detection of antibodies to Echinococcus granulosus.

References

Mayo Clinical and Interpretive Information: Echinococcus Antibody, IgG, Serum
Washington State Notifiable Conditions: Echinococcosis

Synonyms

Alveolar echinococcal disease, Cystic echinococcal disease, Echinococcosis, ECHNG, ECHNO, Hydatic disease, Hydatiosis

Interpretation

Method

Enzyme Immunoassay (EIA)

Ref. Range Notes

Reference Range: Negative

Interpretation:

Negative: The absence of antibodies to Echinococcus species suggests that the individual has not been exposed to this cestode. A single negative result should not be used to rule out infection (see Limitations).
Positive: Results suggest infection with Echinococcus. False-positive results may occur in settings of infection with other helminths or in patients with chronic immune disorders. Results should be considered alongside other clinical findings (eg, characteristic findings on imaging) and exposure history.

Interferences and Limitations

Cautions:

Depending on cyst location, individuals may not develop high enough antibody titers to be detectable by serologic assays, leading to false-negative results. Cysts localized to the lungs, central nervous system, or spleen or cysts that are senescent, calcified, or dead are associated with lower serologic reactivity.

False-positive results may occur in patients with other helminth infections, including with Taenia species, Schistosoma species, and Strongyloides. Careful correlation with imaging findings and exposure history is required.

This assay may not detect antibodies to other species of Echinococcus, including Echinococcus vogeli and Echinococcus oligarthrus, both fairly uncommon causes of hydatid disease in humans.

Guidelines

Washington DOH Notifiable Conditions

Ordering & Collection

Specimen Type: Blood
Collection: 3 mL blood in RED TOP or GOLD TOP SST tube.
Handling Instructions: Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic aliquot. Freeze sample at -20°C while awaiting shipment. Transport on dry ice.

Stability: Refrigerated (preferred): 14 days; Frozen: 30 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia, or heat-inactivated specimen.
Quantity: requested: 0.5 mL serum
minimum: 0.4 mL serum

Processing

Processing

Centrifuge sample and transfer serum to a separate plastic aliquot. Refrigerate serum.

Login: SEND1-;REFRIG

RSNDT1: MAYOSD
RSTYP1: SRM
RTSRQ1: ;Echinococcus Antibody, IgG (Mayo Test ECHNG)

Sendouts:

Order Mayo Test: ECHNG.

Stability: Refrigerated (preferred): 14 days; Frozen: 30 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia, or heat-inactivated specimen.

Performance

LIS Dept Code

Performing Location(s)